Skip to main content
. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Dig Dis Sci. 2013 Dec 31;59(6):1286–1295. doi: 10.1007/s10620-013-3001-6

Fig. 2. Effect of DPPIV inhibition on IND-induced intestinal ulcer formation in rats.

Fig. 2

Intestinal ulcers were induced by IND (10 mg/kg, sc). K579 (0.3 – 3 mg/kg) or vehicle was given intragastrically (ig) or intraperitoneally (ip). Intestinal lesions were evaluated at 24 hrs (Day 1) after IND treatment. A: Intestinal ulcer formation in each segment. The small intestine was divided into 7 segments from duodenum (1) to terminal ileum (7); antrum was defined as segment 0. Each data point represents mean ± SEM (n = 6 rats). *p < 0.05 vs. IND + veh group. B: Total intestinal ulcer score. Each data point represents mean ± SEM (n = 6 rats). *p < 0.05 vs. IND + veh group, †p < 0.05 vs. IND + K579 (0.3 mg/kg, ig) group. C: Portal venous (PV) GLP-2 level on Day 1 after IND treatment with or without K579 pretreatment (0.3 – 3 mg/kg, ig). Each data point represents mean ± SEM (n = 6 rats). *p < 0.05 vs. control, †p < 0.05 vs. IND + veh group.