. Author manuscript; available in PMC: 2014 Oct 14.

Published in final edited form as: Mol Pharm. 2008 Feb 14;5(2):328–339. doi: 10.1021/mp700094s

Table 1.

Fixed and Estimated Receptor Dynamic Parameters

parameter (unit)	definition	value	CV (%)
k_{s_Rm} (fmol/g muscle/h)	GR mRNA synthesis rate constant	0.416	—^a
IC_{50_Rm} (fmol/mg protein)	inhibition constant	0.911	126
k_{d_Rm} (1/h)	GR mRNA degradation rate constant	0.139	18
k_on (1/nmol/h)	association rate constant	0.00269	73
k_re (l/h)	DR(N) overall loss rate constant	0.618	50
R_f	recycling fraction	0.720	12
k_{d_R} (l/h)	GR degradation rate constant	0.0356	27
k_T (l/h)	translocation rate constant	90
k_{s_R} (fmol/mg/(fmol mRNA/g)/h)	GR synthesis rate constant	0.777	^a
GR_mRNA⁰ (fmol/g muscle)	baseline GR mRNA	2.99	8
GR⁰ (fmol/mg protein)	baseline GR	65.3	3

Secondary parameters.