Table 2.
Pharmacodynamic Parameters for Selected Cluster A Genesa
| gene name | accession no.
|
SF
|
kd (h−11)
|
S ((fmol/mg protein)−11) |
Smax
|
SC50 (fmol/mg protein) |
SBS ((fmol/mg protein)−11) |
IC50_BS (fmol/mg protein) |
ke (h−11) |
γ
|
BmRNA_A
|
BmRNA_C
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| acute/chronic | scaling factor |
mRNA degradation rate constant |
stimulatory coefficient |
maximum stimulatory effect |
50% maximum stimulation concentration |
maximum stimulatory effect by biosignal |
50% maximum stimulation concentration |
transit rate constant |
power coefficient |
baseline in acute study |
baseline in chronic study |
|
| Cluster A1 | ||||||||||||
| myogenic factor 6 | M27151_at/1387181_at | 1.634 (23) | 0.0539 (23) | 0.1002 (32) | 0.756 (10) | 1 | ||||||
| phosphatidylserine-specific phospholipase A1 | D88666_at/1370445_at | 0.518 (18) | 0.0838 (19) | 0.3269 (26) | 0.713 (13) | 1 | ||||||
| poly(rC) binding protein 4 | rc_AA891314_at/1371915_at | 1.327 (18) | 0.0643 (20) | 0.09546 (7) | 0.850 (7) | 1 | ||||||
| Cluster A2 | ||||||||||||
| placental growth factor | L40030_at/1368918_at | 0.526 (23) | 0.249 (51) | 2.749 (44) | 2.605 (147) | 0.863 (11) | 1 | |||||
| aryl hydrocarbon receptor nuclear translocator | U08986_s_at/1369244_at | 0.845 (18) | 0.296 (56) | 0.740 (30) | 1.349 (123) | 1 | 1 | |||||
| DnaJ (Hsp40) homologue B5 | rc_AA891542_at/1372144_at | 1.438 (22) | 0.224 (52) | 0.785 (37) | 0.982 (111) | 0.988 (6) | 1 | |||||
| Cluster A3 | ||||||||||||
| multimerin | rc_AI639113_at/1392053_at | 0.809 (8) | 0.065 (93) | 0.0941 (104) | 0.0217 (272) | 0.0155 (19) | 2.85 (66) | 1 | 1 | |||
| phenol sulfotransferase 1A | L19998_at/1370019_at | 1.247 (11) | 0.124 (58) | 0.1898 (57) | 0.0401 (143) | 0.0119 (12) | 3.57 (33) | 0.710 (12) | 1 | |||
| CYP27A1 | M38566mRNA_s_at/1387914_at | 1.576 (13) | 0.113 (64) | 0.0426 (53) | 0.0168 (32) | 0.0144 (10) | 3 | 0.842 (5) | 1 | |||
| Cluster A4 | ||||||||||||
| SH3 domain binding protein CR16 | U25281_at/1370648_a_at | 1.413 (12) | 0.2215 (32) | 0.176 (26) | 3.20 (38) | 0.0088 (47) | 3.89 (166) | 1 | 1 | |||
| peroxisome proliferator activated receptor δ | rc_AI230294_at/1374914_at | 1.01 (17) | 0.0334 (43) | 0.235 (62) | 6.27 (39) | 0.0568 (45) | 2.82 (83) | 1 | 1 | |||
| EST | rc_AA866383_at/1383188_at | 1.117 (37) | 0.0688 (61) | 0.084 (70) | 9.89 (68) | 0.0642 (74) | 3.54 (161) | 0.9173 (7) | 1 | |||
| Cluster A5 | ||||||||||||
| serine/threonine-protein kinase pim-3 | AF086624_s_at/1367725_at | 0.837 (37) | 0.306 (31) | 0.0525 (20) | 0.0273 (76) | 0.00708 (16) | 5 | 0.862 (9) | 0.923 (17) | |||
| endothelin converting enzyme 1 | D29683_at/1367801_at | 0.732 (38) | 0.0704 (69) | 0.0583 (66) | 0.0057 (65) | 0.0106 (14) | 5 | 0.870 (7) | 0.843 (12) | |||
| prostaglandin-endoperoxide synthase 1 | U03388_s_at/1368259_at | 1.499 (37) | 0.0505 (83) | 0.0490 (86) | 0.0034 (77) | 0.0128 (17) | 5 | 1.037 (10) | 0.856 (10) | |||
a
Values are estimates (CV %).