. Author manuscript; available in PMC: 2014 Oct 14.

Published in final edited form as: J Clin Pharmacol. 2006 Apr;46(4):408–417. doi: 10.1177/0091270006286434

Table III.

Pharmacodynamic Parameters for Suppression of Whole Blood and Plasma Histamine Concentrations

		HNMT C314T Genotype

Parameter, units	Definition	C/C Genotype (n = 6)	C/T Genotype (n = 4)	P
Whole blood histamine suppression
$k_{r}^{0}$ , h⁻¹	Production constant	12.6 (7.55 to 27.4)	13.2 (6.00 to 21.9)	NS
k_H, h⁻¹	Loss constant	0.306 (0.196 to 0.34)	0.322 (0.272 to 0.350)	NS
IC₅₀, ng/mL	Inhibition constant	10.1 (2.75 to 224)	8.53 (5.20 to 22.3)	NS
AUEC_SR	Area ratio	0.409 (0.266 to 1.19)	0.408 (0.380 to 0.750)	NS
ABEC, ng•h/mL	Area between response curve	582 (−237 to 823)	411 (262 to 901)	NS
Plasma histamine suppression
AUEC_SR	Area ratio	0.573 (0.317 to 0.700)	0.664 (0.639 to 0.720)	NS
ABEC, ng•h/mL	Area between response curve	3.04 (2.17 to 9.51)	3.17 (2.57 to 4.59)	NS

Data are presented as median (range). Comparisons were made by Wilcoxon rank sum test. NS, not significant.