Figure 3.

Macrophage infiltration in the islet of diabetic pancreas. (A) Only sparse infiltrates of CD68 and CD163 macrophages were found in islets in non-diabetic group (ND) or amyloid-free diabetic group (DA−). In contrast, there were increased infiltrates of CD68 cells in the islets in amyloid-rich diabetic group (DA+). (B) Quantification demonstrated a significant increase in the population of CD68 cells in DA+ (*p < 0.001 versus ND and DA−), while the infiltrates of CD163 cells were not significant. The ratio of CD68 to CD163 cells was significantly greater in DA+ compared to those in ND and DA− (†p < 0.001). Infiltration of CD68 cells paralleled with amyloid volume density (p < 0.05).