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. 2014 Jul 9;21(3):191–201. doi: 10.3109/13506129.2014.937857

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Figure 6. — In situ hybridization of (pro)insulin mRNA in investigated subjects (n = 6 in each group). (A) There were strong positive signals in the cytoplasm of β-cells in the islet of non-diabetic subjects (ND). The reaction was slightly but not significantly reduced in amyloid-free diabetic group (DA−). There was marked reduction of (pro)insulin mRNA expression in amyloid-rich diabetic group (DA+). (B) Semi-quantitative evaluation confirmed significant reduction of insulin mRNA expression in DA+ compared to those in ND and DA− (*p < 0.05).