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. 2014 Apr 10;28(1-2):53–69. doi: 10.3109/01677063.2014.882918

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© 2014 Informa Healthcare USA, Inc.

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Figure 4. — Hypothetical model of pyramidal cell dysfunction in schizophrenia. It is hypothesized that as a result of disinhibition-induced excitotoxic insult (see text for details), TGFβ signaling within pyramidal neurons is up-regulated, which may contribute to extracellular matrix abnormalities, dysregulated apoptosis, and impaired synaptic and cytoskeletal plasticity. Shown in this highly simplified diagram are some of the hub genes that can be targeted in future experiments in the testing of this hypothesis.