Figure 6.

Tumor panels from Z138 tumor-bearing mice showing mantle cell NHL of Z138 human cell line: (A) (× 400 hematoxylin and eosin [H&E]) shows “starry sky” pattern as a result of apoptosis and phagocytosis; (B) (× 100 H&E) highlights infiltrative growth into surrounding subcutaneous tissue (muscle and fat), lacking distinct encapsulation (left; #101), respectively, with formation of a thin tumor-surrounding capsule of tumors of vehicle-treated mice (right, #102); (C) (× 200 CD20) shows strong membrane-bound CD20 expression in almost all MCL cells; (D) (× 100 H&E) demonstrates improved demarcation with increased capsule thickness after treatment with obinutuzumab (GA101) and bendamustine (left, #501) or after treatment with rituximab and bendamustine (right, #602). Note the small rim in the periphery of the tumor with increased vacuolated/degenerative and apoptotic tumor cells.