Table 1.
Comparison of properties of Kv4-induced K+ currents.
| Control |
Hypoxia 6 h |
Hypoxia 12 h |
||||
|---|---|---|---|---|---|---|
| Kv4.2 | Kv4.2/Kv4.3 | Kv4.2 | Kv4.2/Kv4.3 | Kv4.2 | Kv4.2/Kv4.3 | |
| V1/2 activation (mV) | -3.26 ± 0.96 | -10.25 ± 0.65 | -5.42 ± 1.56 | -7.36 ± 0.70 | -5.59 ± 1.64 | -7.48 ± 0.80 |
| kact | 15.95 ± 0.89 | 15.97 ± 0.60 | 18.71 ± 1.51 | 15.89 ± 0.64 | 19.12 ± 1.60 | 15.961 ± 0.74 |
| Activation T (ms) (+40 mV) | 1.23 ± 0.17 | 0.97 ± 0.04 | 1.68 ± 0.13* | 2.53 ± 0.23*** | 2.19 ± 0.22** | 1.99 ± 0.23*** |
| V1/2 inactivation (mV) | -54.66 ± 1.48 | -42.07 ± 0.72 | -55.96 ± 1.09 | -45.58 ± 0.74 | -53.84 ± 0.72 | -49.37 ± 0.73 |
| kinact | -0.04 ± 0.005 | -0.07 ± 0.007 | -0.04 ± 0.003 | -0.06 ± 0.005 | -0.05 ± 0.003 | -0.05 ± 0.004 |
| Inactivation T (ms) | 35.97 ± 6.36 | 36.48 ± 1.99 | 57.45 ± 7.39 | 49.63 ± 5.35 | 44.64 ± 4.97 | 35.97 ± 6.36 |
| (+40 mV) | 202.60 ± 36.78 | 200.80 ± 22.28 | 245.90 ± 40.84 | 233.50 ± 46.28 | 220.70 ± 41.49 | 213.00 ± 35.91 |
| Recovery τ (ms) | 94.84 ± 9.94 | 37.26 ± 4.83 | 91.24 ± 12.9 | 93.15 ± 15.22*** | 86.32 ± 8.36 | 66.55 ± 7.44** |
All data were obtained at room temperature (20–22°C) and are expressed as Mean ± SEM of 10 to 15 cells from each group. *p < 0.05, **p < 0.01, ***p < 0.001, all compared with control.