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. 2014 Oct 14;5:160. doi: 10.3389/fendo.2014.00160

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Copyright © 2014 Lennon, Randles and Humphries.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular components of the podocyte slit diaphragm. Podocyte slit diaphragms contain unique components, including nephrin, Neph family proteins, and podocin in addition to components of tight, gap, and adherens junctions, such as the cadherin-3 and FAT1. The adaptor proteins Nck1/2, CD2AP, and Crk1/2, Src family kinases, in addition to many more kinases and actin binding proteins localize to the podocyte slit diaphragm. The interactions between nephrin and other Neph proteins are thought to be homo- and heterophilic and recent structural analysis of the orthologs SYG1/2 has suggested an angled conformation (152) as depicted in this schematic.