Figure 2.

Effect of gene deletions on 2DG resistance. Wild-type yeast cells and the 19 knockouts strains identified by Ralser et al. (2008) were grown in the absence or presence of increasing concentrations of 2DG in rich media with glucose as the carbon source. Deletion of 15 genes provide no significant resistance to 2DG relative to wild-type yeast (A). Deletion of the REG1 and HXK2 genes provides strong resistance to 2DG relative to a wild-type strain (B). Deletion of the LSM6 and DHH1 genes provides weak 2DG resistance relative to a wild-type strain (C).