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. 2014 Oct 14;8:318. doi: 10.3389/fncel.2014.00318

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Copyright © 2014 Skardelly, Gaber, Burdack, Scheidt, Schuhmann, Hilbig, Meixensberger and Boltze.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophage and microglia activity after hNPC transplantation. Macrophage density as indicated by CD68 staining was increased at all investigated time points in animals receiving local or systemic hNPC transplantation (A–D). Statistically significant differences were observed at 84 days after systemic cell transplantation in the area of the trauma, the corpus callosum and the basal ganglia (B,D). A similar picture was observed for CD11b microglia. Apart from basal ganglia at early stages, highest mean numbers of these cells were observed at all investigated time points in both treatment groups (E,F). Significantly enhanced numbers of microglia were detected 84 days after systemic cell transplantation in the perilesional cortex and the basal ganglia (F). *p < 0.05.