Table 2.
Age-adjusted and multivariate* RR of constitutional risk factors for multiple non-melanoma skin cancers
| 1 NMSC | 2–4 NMSCs | 5–10 NMSCs | 11+ NMSCs | ||
|---|---|---|---|---|---|
| Age | Age only | 1.00 | 1.11 (1.08–1.13) | 1.14 (1.10–1.18) | 1.22 (1.15–1.29) |
| MV adjusted | 1.00 | 1.12 (1.10–1.15) | 1.17 (1.13–1.21) | 1.27 (1.20–1.35) | |
| Male | Age adjusted | 1.00 | 1.61 (1.47–1.75) | 2.14 (1.88–2.44) | 2.36 (1.92–2.89) |
| MV adjusted | 1.00 | 1.65 (1.49–1.82) | 2.28 (1.96–2.64) | 2.75 (2.18–3.47) | |
| Skin reaction to the sun (ref. tan) | |||||
| Burn then tan | Age adjusted | 1.00 | 1.29 (1.18–1.40) | 1.40 (1.23–1.60) | 1.55 (1.24–1.93) |
| MV adjusted | 1.00 | 1.20 (1.10–1.30) | 1.24 (1.08–1.42) | 1.26 (1.00–1.58) | |
| Painful burn | Age adjusted | 1.00 | 1.53 (1.39–1.68) | 2.08 (1.81–2.39) | 2.79 (2.24–3.48) |
| MV adjusted | 1.00 | 1.34 (1.21–1.48) | 1.63 (1.40–1.90) | 1.91 (1.50–2.43) | |
| Number of severe sunburns (ref. none) | |||||
| 1–2 | Age adjusted | 1.00 | 0.95 (0.81–1.11) | 1.06 (0.81–1.37) | 0.89 (0.55–1.45) |
| MV adjusted | 1.00 | 0.92 (0.79–1.08) | 1.02 (0.78–1.33) | 0.84 (0.52–1.36) | |
| 3–5 | Age adjusted | 1.00 | 1.08 (0.94–1.24) | 1.34 (1.06–1.70) | 1.44 (0.95–2.19) |
| MV adjusted | 1.00 | 1.02 (0.89–1.18) | 1.24 (0.97–1.57) | 1.29 (0.85–1.96) | |
| 6–9 | Age adjusted | 1.00 | 1.22 (1.05–1.41) | 1.50 (1.18–1.92) | 1.71 (1.12–2.62) |
| MV adjusted | 1.00 | 1.12 (0.97–1.30) | 1.33 (1.04–1.70) | 1.45 (0.94–2.22) | |
| 10+ | Age adjusted | 1.00 | 1.44 (1.27–1.64) | 2.24 (1.80–2.79) | 3.18 (2.17–4.66) |
| MV adjusted | 1.00 | 1.24 (1.08–1.42) | 1.76 (1.40–2.21) | 2.33 (1.57–3.46) | |
| Family history of melanoma (ref. no) | |||||
| Yes | Age adjusted | 1.00 | 1.19 (1.05–1.35) | 1.27 (1.05–1.54) | 1.27 (0.93–1.73) |
| MV adjusted | 1.00 | 1.17 (1.03–1.33) | 1.24 (1.02–1.50) | 1.23 (0.90–1.69) | |
| Natural hair colour (ref. dark brown hair) | |||||
| Black | Age adjusted | 1.00 | 0.94 (0.78–1.14) | 0.96 (0.72–1.28) | 0.80 (0.48–1.35) |
| MV adjusted | 1.00 | 0.94 (0.78–1.14) | 0.96 (0.72–1.29) | 0.82 (0.49–1.38) | |
| Light brown | Age adjusted | 1.00 | 1.10 (1.02–1.19) | 1.10 (0.97–1.24) | 1.30 (1.06–1.61) |
| MV adjusted | 1.00 | 1.06 (0.97–1.14) | 1.02 (0.90–1.15) | 1.17 (0.95–1.44) | |
| Blonde | Age adjusted | 1.00 | 1.25 (1.12–1.40) | 1.26 (1.07–1.50) | 1.69 (1.30–2.21) |
| MV adjusted | 1.00 | 1.15 (1.03–1.28) | 1.10 (0.92–1.31) | 1.38 (1.06–1.81) | |
| Red | Age adjusted | 1.00 | 1.53 (1.29–1.80) | 2.06 (1.64–2.59) | 2.26 (1.56–3.27) |
| MV adjusted | 1.00 | 1.29 (1.09–1.53) | 1.52 (1.20–1.94) | 1.46 (0.99–2.14) | |
| Nevi on left arm (ref. none) | |||||
| 1–2 | Age adjusted | 1.00 | 1.13 (1.04–1.24) | 1.04 (0.91–1.19) | 1.15 (0.92–1.43) |
| MV adjusted | 1.00 | 1.13 (1.04–1.23) | 1.04 (0.91–1.20) | 1.15 (0.92–1.44) | |
| 3–5 | Age adjusted | 1.00 | 1.16 (1.02–1.31) | 1.12 (0.92–1.36) | 1.10 (0.79–1.53) |
| MV adjusted | 1.00 | 1.15 (1.01–1.30) | 1.11 (0.91–1.36) | 1.08 (0.78–1.51) | |
| 6+ | Age adjusted | 1.00 | 1.30 (1.11–1.52) | 1.48 (1.18–1.87) | 1.59 (1.11–2.29) |
| MV adjusted | 1.00 | 1.26 (1.08–1.48) | 1.42 (1.12–1.79) | 1.49 (1.03–2.14) | |
*
Multivariate regression for a given exposure of interest uses all other exposures as covariates