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. Author manuscript; available in PMC: 2014 Oct 14.
Published in final edited form as: J Pain. 2014 Feb 10;15(5):535–549. doi: 10.1016/j.jpain.2014.01.498

Table 1. KEGG Pathway Analysis Based on the Microarray Data of the Genes That Are Differentially Up- and Down-Regulated in the ACU and CON Groups.

Up/Down KEGG Pathway Number of Genes Probe ID Gene Symbol P Value
↑ MAPK signaling pathway 3 10397346 fos .04
10427035 nr4a1
10449284 dusp1
↑ B-cell receptor signaling pathway 2 10397346 fos .016
10400405 nfkbia
↑ T-cell receptor signaling pathway 2 10397346 fos .032
10400405 nfkbia
↑ Toll-like receptor signaling pathway 2 10397346 fos .04
10400405 nfkbia
↑ Circadian rhythm 1 10377439 per1 .036
↑ C21-steroid hormone metabolism 1 10407435 akr1c18 .039
↑ p53 signaling pathway 2 10474700 thbs1 .019
10534667 serpine1

Abbreviation: KEGG, Kyoto Encyclopedia of Genes and Genomes.

NOTE. Pathways were clustered after gene expression analysis. Seven pathways changed significantly (P < .05), and the MAPK signaling pathway included the most genes. (Student t-test compared to the CON group, each n = 3).