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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Virology. 2014 Aug 3;0:213–217. doi: 10.1016/j.virol.2014.07.012

Figure 2. MHC restriction of the cross-reactive epitopes.

Figure 2

This figure plots the CD8 T cell responses to the defined cross-reactive LCMV and PV NP313 epitopes under conditions of LCMV + PV heterologous immunity, as described in Table 1. This plots the activity in PEC CD8 T cells at day 4 post-infection. Here, the B10 series of mice is examined, and only those expressing H2d (B10.D2, like the H2d –expressing BALB/c mice (Figure 1)), show positive reactivity to the two peptides, thereby demonstrating MHC-restriction.