Fig. 1.

Structure of the human CYP2R1 gene. The predicted exon–intron structure of the human CYP2R1 gene is shown together with six pairs of oligonucleotides used to amplify and sequence fragments of the DNA. Exon 3 was amplified with primer pair 5, 8, and was sequenced with primers 5, 6, 7, and 8. The gene is drawn to scale with the exception of intron 1, which is estimated to be 9.1 kb in length. The autosomal location of the gene was deduced from the Human Genome database, which can be accessed at www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=11.