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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Am J Transplant. 2014 Aug 4;14(9):2173–2180. doi: 10.1111/ajt.12799

Figure 2. ATP-competitive mTOR inhibition suppresses T cell proliferation at physiologic levels to a greater degree than that of RAPA.

Figure 2

B6 CD3+ T cells were stimulated with CD3/CD28 T-Activator Dynabeads for 5 days in the presence of increasing concentrations of RAPA or AZD8055 added at the start of culture. (A) CD4+ or (B) CD8+ T cell proliferation was determined by CFSE dilution and calculated as percent suppression by the indicated mTOR inhibitor compared to T cells stimulated in the absence of inhibitor. * p<0.05 versus the same concentration of RAPA or AZD8055 for n=3–4 experiments per data point.