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Pharmacokinetic parameters of AZD8055 and Rapamycin
| Parameter | AZD8055 | Rapamycin |
|---|---|---|
| Disposition rate constant | 0.205 h−1 | 0.141 h−1 |
| Half life (T1/2) | 3.4 h | 4.9 h |
| AUC 0-infinity | 26.2μg/ml/h | 1.93μg/ml/h |
| Apparent Clearance (CL/F*) | 7.6 ml/h | 8.64 ml/h |
| Apparent volume of distribution | 37 ml | 74 ml |
F, fraction that is bioavailable
