Table 1. Rate of ura4 loss.
| Strains | Rate of ura4 Loss ×10−8 (Event/Cell/Generation)a | Fold Increase by RFB (OFF/ON) | Fold VARIATION over wt b |
| wt RFB OFF | 1.6±0.2 | ||
| wt RFB ON | 17.8±3.1 | 11.1 | |
| rad52-d RFB OFF | 120 | Decreased by 8.5 (p<0.01) | |
| rad52-d RFB ON | 161 | 1.3 | |
| pcf1-d RFB OFF | 2.1±0.8 | Decreased by 5 (p<0.0001) | |
| pcf1-d RFB ON | 5.9±1.5 | 2.8 | |
| pcf2-d RFB OFF | 2.4±0.6 | Decreased by 3.3 (p<0.003) | |
| pcf2-d RFB ON | 8.1±1.1 | 3.4 | |
| pcf3-d RFB OFF | 2.2±0.8 | Decreased by 3 (p<0.01) | |
| pcf3-d RFB ON | 8.2±0.3 | 3.7 | |
| pcf1-PIPmut RFB OFF | 2.3±0.3 | Decreased by 3.8 (p<0.00003) | |
| pcf1-PIPmut RFB ON | 6.7±0.9 | 2.9 | |
| rqh1-d RFB OFF | 7.3±1.4 | Increased by 2.9 (p<2.10-6) | |
| rqh1-d RFB ON | 232±6.5 | 31.8 | |
| rqh1-d pcf1-d RFB OFF | 6.3±1.4 | Increased by 1.3 (p<0.01) | |
| rqh1-d pcf1-d RFB ON | 92.1±8.7 | 14.6 |
a
The values reported are means of at least three independent median rates ±SD.
b
Statistical significance was calculated using the nonparametric Mann–Whitney test.