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Activation of group 1 mGluRs attenuates OL excitotoxicity. (A) Effect of various mGluR modulators on kainate-(50 μM) or OGD-(2 h) induced OPC death at 24 h. (B) Dose response of the effect of DHPG on kainate-(50 μM) or OGD-(2 h) induced OPC death at 24 h in the absence or presence of the mGluR antagonist MCPG (500 μM).
