Fig. 3.

Effect of AMPH on DA clearance in the core and shell NAc in WT and DAT-KO mice measured by FSCV in brain slices. AMPH was applied to the NAc at 1 (gray bars) and 10 (white bars) μM. Each concentration was tested in one slice, which served as its own precondition control (black bars). For each experimental group, slices were obtained from four to five animals. The rate of DA clearance, reported as a rate constant k, was significantly and dose-dependently decreased by AMPH in both the core and shell of the NAc in WT mice. AMPH had no effect on DA clearance in either the NAc core or shell of DAT-KO mice. The data are presented as mean ± SEM. Differences with P < 0.05 are indicated with asterisks.