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. 2014 Oct 14;9(10):e109416. doi: 10.1371/journal.pone.0109416

Figure 6. γδT cell deficiency reduces neutrophilia and lymphopenia in ApoE KO mice.

Figure 6

Blood leukocytes were stained with anti-Ly6G-FITC, anti-Ly6B(7/4)-PE, anti-CD11b-PERCP Cy5.5 and anti-Ly6C-APC. A: Representative FACS plots; X and Y axes are log fluorescence intensity, as in Figs 1 & 3. Neutrophils are Ly6Bhi Ly6Ghi(top); inflammatory monocytes are Ly6G−, Ly6Bhi, CD11b+, Ly6Chi (bottom). Blood neutrophils and Ly6Chi monocytes are increased in ApoE KO (n = 14) vs. B6 (n = 6) mice; γδT cell deficiency (n = 9) reduces neutrophilia (C) but not Ly6Chi monocyte levels (D). Circulating CD3+ T cells are decreased in ApoE KO, but not ApoE/γδT DKO, vs. B6 mice (E). γδT cells are decreased in ApoE KO vs. B6 mice, and absent in ApoE/γδT DKO mice. *p<0.05, **p<0.01 vs. B6; + p<0.05 vs. ApoE KO.