Table 1.
Summary of meta-analyses of randomized controlled trials for the effect of latanoprost and other PG analogs on IOP in patients with glaucoma or ocular hypertension
| Study | PG analogs | Other drugs assessed | Studies (n) | Patients (n) | Duration | Primary efficacy variables |
|---|---|---|---|---|---|---|
| Cucherat et al50 | LAT (BAK-preserved and preservative-free), BIMf (BAK-preserved), TRA (preserved with BAK, polyquaternium-1 or sofzia), TAF (BAK-preserved) | None | 21 | Not reported | ≥2 months | Preservative-free LAT significantly more effective than TAF regarding IOP at 3 months. No significant difference between other PG analogs. |
| Orme et al42 | LAT, BIM, TRA | TIM | 18 | 2,943 | 3 months | No significant difference between LAT and BIM in on-treatment IOP. LAT and BIM significantly more effective than TIM. No significant difference between TRA and TIM. |
| Cheng et al43 | LAT, BIM, TRA | TIM | 9 | 1,090 | 2 weeks to 3 months | No significant difference in IOP-lowering effect from baseline between LAT, BIM, TRA, and TIM. |
| Cheng et al44 | LAT, BIM | TIM, DOR, BRIM | 15 | 450 | 3 weeks to 2 months | No significant difference between LAT and BIM in IOP reduction from baseline at peak, trough, and diurnal assessments. |
| Eyawo et al41 | LAT, BIM, TRA | None | 15 | 2,755 | 3–12 months | No significant differences in IOP-lowering effects at study conclusion between LAT, BIM, and TRA. |
| Aptel et al45 | LAT, BIM, TRA | None | 8 | 1,610 | 1–6 months | Significantly greater change in IOP with BIM than LAT at 8 am, noon, 4 pm, and 8 pm after 3 months. No significant difference between LAT and TRA. |
| Cheng and Wei46 | LAT, BIM | None | 13 | 1,302 | 1–6 months | Percentage reduction in morning IOP significantly greater with BIM than LAT at 1, 3, and 6 months. |
| Stewart et al48 | LAT, BIM, TRA | TIM, DOR, BRIM | 11 | 386 | 1–2 months | No significant differences reported in the publication between LAT, BIM, and TRA in 24-hour IOP efficacy. |
| Denis et al49 | LAT, BIM, TRA | None | 9 | 1,318 | 2 weeks to 12 months | No significant difference between LAT and BIM or TRA in IOP levels at the end of follow-up. |
| Van der Valk et al47 | LAT, BIM, TRA | TIM, DOR, BRIM, BET, BRIN | 28 | 6,953 (trough) 6,841 (peak) | 1–6 months | No significant difference between LAT, BIM, and TRA in IOP change from baseline at 1 month. |
Note:
f
0.01% and 0.03%.
Abbreviations: BAK, benzalkonium chloride; BET, betaxolol; BIM, bimatoprost (0.03%); BRIN, brinzolamide; BRIM, brimonidine; DOR, dorzolamide; IOP, intraocular pressure; LAT, latanoprost (0.005%); PG, prostaglandin; TAF, tafluprost (0.0015%); TIM, timolol; TRA, travoprost (0.004%).