Table 1. Cytokine profile in serum measured by CBA.
CONTROL | COLITIS | COLITIS+curSmSWP | COLITIS+prevSmSWP | |
CBA serum (pg/ml) | ||||
IL-2 | 0.0±0.0 | 0.8±0.3# | 0.5±0.2 | 0.3±0.1 |
IFN-γ | 0.0±0.0 | 22.6±8.8 | 38.6±19.3# | 17.5±6.9 |
TNF | 3.0±0.6 | 83.6±12.5# | 79.7±19.4# | 75.0±11.5# |
IL-6 | 0.0±0.0 | 8.1±1.8# | 7.9±2.4# | 4.5±1.0 |
IL-17A | 1.4±0.7 | 6.1±0.8 | 4.8±1.5 | 14.7±5.8# , * |
IL-4 | 0.0±0.0 | 0.0±0.0 | 0.6±0.6 | 0.0±0.0 |
IL-10 | 2.7±0.9 | 3.7±0.8 | 3.8±0.8 | 2.3±0.9 |
Data are presented as mean ± SEM. One-way ANOVA with LSD post-hoc test was used to compare the results between the CONTROL, COLITIS and COLITIS+curSmSWP groups or between CONTROL, COLITIS and COLITIS+prevSmSWP groups.
: P≤0.05, significantly different from CONTROL group;
*: P≤0.05, significant difference between COLITIS and COLITIS+prevSmSWP groups. N = 9–12 per animal group. Abbreviations: CBA: cytometric bead array; cur: curative; IFN-γ: interferon-γ; IL: interleukin; prev: preventive; SmSWP: Schistosoma mansoni soluble worm proteins; TNF: tumor necrosis factor.