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. 2014 Oct 14;9(10):e110580. doi: 10.1371/journal.pone.0110580

Figure 4. Effect of Lin28a overexpression or knockdown on insulin-PI3K-mTOR signaling pathway and AMPK- PGC-1α signaling pathway activation.

Figure 4

Representative gel bolts depicting respective protein expression levels using specific antibodies (A, G); IGF1R (B); phosphorylated IRS-1 (p-IRS-1) (C); phosphorylated Akt (p-Akt) (D); phosphorylated mTOR (p-mTOR) (E); phosphorylated p70s6k (p-p70s6k) (F); phosphorylated AMPK (p-AMPK) (H); Ace-lysine-PGC-1α (I); Nrf-1(J); Tfam(K). The columns and error bars represent means and SD. Data were obtained from at least three independent experiments. *P<0.05 vs. H/R, #P<0.05 vs. H/R+Lin28a.