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. 2014 Oct 14;9(10):e110428. doi: 10.1371/journal.pone.0110428

Figure 2. Defective insulin signaling impairs basal brite state while still allowing efficient brite recruitment in WAT.

Figure 2

(A) mRNA expression of UCP-1, CIDEA, CPT-1β, COX7a1, COX8b in inguinal white adipose tissue (iWAT) of mice injected with streptozotocin (STZ, 60 µg/day/g bw) and control mice or (B) of 12 weeks low fat diet (LFD) or high fat diet (HFD) fed mice implanted with CL316,243 (CL, dose of 1 µg/g/day) or control (NaCl) loaded s.c. osmotic pumps for 10 days. (C) UCP-1 stained iWAT slices of mice fed LFD or HFD for 12 weeks implanted with NaCl or CL s.c. pumps. All values in bar graphs are expressed as means ± SEM, n = 7–10, #p<0.05, ##p<0.01, ###p<0.001 NaCl vs. CL, *p<0.05, **p<0.01, ***p<0.001 control vs. STZ and LFD vs. HFD treated animals, respectively.