Figure 1. Structural polymorphism in CagA.
Western-type CagA contain the EPIYA-A, EPIYA-B and EPIYA-C segments, whereas east Asian-type CagA contain the EPIYA-A, EPIYA-B and EPIYA-D segments. EPIYA-motif in each segment represent the tyrosine phosphorylation sites of CagA. The asterix means that the nucleotide sequences are the same between western-type CagA and east Asian-type CagA.