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. 2014 Oct 15;127(20):4531–4541. doi: 10.1242/jcs.156760

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — . Illustration of the likely cytoplasmic microdomain within the junction between the T-tubule and the sarcoplasmic reticulum in a cardiac myocyte. The width of the junction is similar to the width of the transverse (T)-tubule and sarcoplasmic reticulum (SR) membranes that form its borders. The cleft contains cytoplasmic domains of the DHPR and NOX2 embedded in the T-tubule membrane and JP2, RyR2, triadin and junctin embedded in the sarcoplasmic reticulum membrane, in addition to many other identified junctional components that are not shown.