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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Eur J Immunol. 2014 Aug 12;44(10):2938–2948. doi: 10.1002/eji.201444751

Figure 3. Comparison of NK cell responses between KIR2DL1-3+ and KIR2DL1-3(−) NK cell subsets in primary HIV-1 infection.

Figure 3

Functional assessment of KIR2DL1-3-expressing NK cell subsets in HIV-1(+) individuals carrying at least one copy of the cognate HLA-C group allele (KIR2DL1+/HLA-C2+; KIR2DL2/3+/HLA-C1+): (A) Paired comparison between KIR2DL1 single-positive NK cells and KIR-negative NK cells (n=24); (B) paired comparison between KIR2DL2/3 single-positive NK cells and KIR-negative NK cells (n=32). Single-positive KIR NK cells are defined as expressing either KIR2DL1, or KIR2DL2/3 but not KIR3DL1. KIR-negative NK cells are defined by the absence of KIR2DL1, KIR2DL2/3 and KIR3DL1 on the cell surface. Scatter plots display frequency of CD107a+, IFN-γ and TNF-α producing NK cells as well as percentage of polyfunctional NK cells (CD107a+/IFN-γ+/TNF-α+) for each individual. Wilcoxon matched-pairs signed rank test for paired values was used to test for differences between groups.