Table 3.
Frequency of BCL2 gene abnormality with copy number and mRNA levels in DLBCL.
| BCL2 Gene Status n (%) |
P | |||
|---|---|---|---|---|
| Translocation(+)a | Amplification(+)a | Chrs. 18 Polysomy(+)a | ||
| DLBCL, all subtypes | 15/73 (20.5) | 29/61 (47.5) | 8/61 (13.1) | |
| ABC | 2 (6.7) | 12 (52.2) | 3 (13.0) | 0.564c |
|
| ||||
| Non-GCBb | 3 (8.6) | 16 (53.3) | 3 (10.0) | |
| GCB | 10 (35.7) | 10 (41.7) | 4 (16.7) | 0.009d |
|
| ||||
| BCL2 mRNA level | ||||
| Average log2 transformed | 5.9 | 7.1 | 5.5 | 0.049 |
a
Total “n” differs for the translocation and amplification/polysomy categories due to the different pass rates for each of the Dual ISH assays. The “n” for each variable is as follows: ABC, n=30 (translocation (+)) and 23 (amplification/polysomy (+)); Non-GCB, n=35 and 30; and GCB, n=28 and 24.
b
non-GCB subtype includes ABC and unclassifiable as determined by GEP and non-GCB as determined by IHC according to Hans classification (15).
c,d
P-values calculated for difference between translocation(+)c and amplification(+)d cases in the ABC and GCB subtypes.