Table 2.
BMI, CD4 Count and lipid levels at ≥48 weeks on second-line ART
| 48 weeks after switch to second-line | n (%) | TC mean (se) | †P | LDL-C mean (se) | †P | HDL-C mean (se) | †P | TG mean (se) | †P | TC/HDL-C ratio mean (se) | †P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| All | 65 | 5.4 (0.2) | 2.9 (0.1) | 1.2 (0.05) | 1.9(0.2) | 4.9 (0.3) | |||||
| Sex | |||||||||||
| Females | 31 (48%) | 5.8 (0.2) | 0.03 | 3.2 (0.2) | 0.003 | 1.3 (0.07) | 0.03 | 1.8 (0.2) | 0.71 | 4.6 (0.2) | 0.69 |
| Males | 34 (52%) | 5.1 (0.2) | 2.5 (0.1) | 1.1 (0.06) | 2.0 (0.2) | 5.1 (0.4) | |||||
| BMI (kg/m2) | |||||||||||
| <18.5 | 4 (6%) | 4.8 (0.4) | 0.04 | 2.6 (0.5) | 0.05 | 1.2 (0.3) | 0.57 | 1.0 (0.2) | 0.003 | 4.6 (0.9) | 0.55 |
| 18.5-24.9 | 36 (56%) | 5.2 (0.2) | 2.7 (0.2) | 1.2 (0.1) | 1.5 (0.1) | 5.0 (0.4) | |||||
| 25-29.9 | 21 (32%) | 5.8 (0.3) | 3.1 (0.2) | 1.2 (0.1) | 2.4 (0.3) | 4.8 (0.4) | |||||
| 30-39.9 | 4 (6%) | 5.9 (0.3) | 3.1 (0.4) | 1.2 (0.4) | 2.8 (1.1) | 5.0 (1.0) | |||||
| CD4 cell/mm3 | |||||||||||
| <100 | 2 (3%) | 4.6 (0.9) | 0.93 | 2.6 (0.6) | 0.28 | 1.1 (0.1) | 0.10 | 0.8 (0.02) | 0.24 | 4.2 (1.1) | 0.31 |
| 100-199 | 10 (15%) | 5.7 (0.2) | 3.0 (0.2) | 1.4 (0.1) | 1.8 (0.5) | 4.1 (0.4) | |||||
| ≥200 | 53 (82%) | 5.4 (0.2) | 2.8 (0.1) | 1.2 (0.1) | 1.9 (0.2) | 5.1 (0.3) |
TC: total cholesterol, LDL-C: low density lipoprotein–cholesterol, HDL-C: high density lipoprotein–cholesterol, TG: triglyceride, BMI: Body mass index. All lipid levels are expressed in mmol/L.
†P-values for continuous BMI and CD4 vs. lipids calculated using Spearman correlation.