Table 4.
Multivariable linear regression analyses for factors associated with changes in lipid levels from switch to ≥48 weeks on second-line ART
| At switch to second- line * | n (%) or median (IQR) | TC effect (se) | P | LDL-C effect (se) | P | HDL-Ceffect (se) | P | TG effect (se) | P |
|---|---|---|---|---|---|---|---|---|---|
| Gender | |||||||||
| Females | 32 (48%) | +04 (0.3) | 0.14 | +0.5 (0.2) | 0.04 | +0.1 (0.08) | 0.26 | −0.07 (0.3) | 0.81 |
| Age (per 10 year increase) | 38 (34-43) | +0.4 (0.2) | 0.02 | +0.3 (0.1) | 0.06 | +0.1 (0.06) | 0.02 | −0.04 (0.2) | 0.87 |
| BMI (kg/m2) per 2 units | 21 (17-26) | +0.02 (0.03) | 0.47 | +0.02 (0.03) | 0.41 | −0.02 (0.01) | 0.08 | +0.08 (0.04)§ | 0.07 |
| NVP | 50 (77%) | +1.3 (0.4) | 0.004 | +0.6 (0.3) | 0.10 | +0.6 (0.2) | <0.001 | +0.4 (0.6) | 0.43 |
| EFV | 9 (14%) | +1.6 (0.5) | 0.003 | +0.9 (0.4) | 0.03 | +0.4 (0.2) | 0.02 | +0.4 (0.6) | 0.57 |
| ddI | 34 (52%) | −0.04 (0.3) | 0.88 | −0.1 (02) | 0.54 | −0.1 (0.1) | 0.21 | +0.2 (0.3) | 0.54 |
Al l models are adjusted for baseline lipid level.
§BMI at week 48 (rather than at switch to second-line) as this was a better predictor.
*Reference category: man aged 40 years with BMI 25 at switch, receiving LPV/r plus NRTIs (no NNRTI) without ddI as their second-line regimen.