Table 4.
Univariate and multivariate analysis of clinical and echocardiographic determinants of NYHA class improvement
| NYHA improvement | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR(95% CI) | p | p | ||
| Female gender [n(%)] | 0.92 (0.31-2.67) | 0.87 | ||
| Age (years) | 1.09 (1.01-1.17) | 0.02 | ||
| ΔEF (%) | 0.99 (0.94-1.04) | 0.62 | ||
| ΔLVMI (g/ m 2 ) | 0.99 (0.97-1.01) | 0.49 | ||
| ΔLAVI (ml/ m 2 ) | 1.01 (0.99-1.02) | 0.38 | ||
| ΔLVDVI (ml /m 2 ) | 0.98 (0.94-1.02) | 0.28 | ||
| ΔLVSVI (ml/ m 2 ) | 0.99 (0.93-1.05) | 0.64 | ||
| ΔEAOI (%) | 8.81 (0.90-86.10) | 0.06 | 3.87 (1.02-14.70) | 0.004 |
| ΔE/ e’ | 1.01 (0.94-1.08) | 0.85 | ||
| Hypertension [ n(%)] | 1.70 (0.60-5.15) | 0.35 | ||
| Diabetes Mellitus [n(%)] | 0.48 (0.15-1.48) | 0.20 | ||
| COPD [n(%)] | 2.55 (0.75-8.66) | 0.14 | ||
| PAD [n(%)] | 0.80 (0.22-2.96) | 0.74 | ||
| NYHA class ≥ III [n(%)] | 11.33 (2.93-43.78) | <0.001 | 8.81 (2.13-36.52) | 0.003 |
| TAVI [ n(%)] | 7.08 (1.86-27.04) | 0.004 | ||
| Aortic regurgitation 6m [ n(%)] | 2.35 (0.69-8.03) | 0.17 |
LVDVI = left ventricular end-diastolic volume index; LVSVI = left ventricular end-systolic volume index;; LVMI = left ventricular mass index; LAVI = left atrial volume index; Δ EF = baseline- 6 months ejection fraction; Δ LVDVI = baseline- 6 months LVDVI; Δ LVSVI = baseline- 6 months LVSVI; Δ LVMI = baseline- 6 months LVMI; Δ LAVI = baseline- 6 months LAVI; Δ EAOI = relative increase in EAOI at 6 months; Δ E/e’ = baseline- 6 months E/e’; COPD = chronic obstructive pulmonary disease; PAD = peripheral artery disease; TAVI = transcatheter aortic valve implantation.