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. 2014 Oct 10;7:76. doi: 10.1186/s13045-014-0076-2

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© Yang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Transcriptome sequencing of 11 osteosarcomas revealed two hotspots of chromosomal rearrangement. One hotspot in 17p was associated with TP53-disrupting rearrangements. The second hotspot in 12q was associated with MDM2/CDK4 co-amplification.