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. 2014 Oct 10;7:76. doi: 10.1186/s13045-014-0076-2

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© Yang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promoted human osteosarcoma SAOS-2 cells motility relative to empty vector. (A) Transwell migration assay. Both the LRP1-SNRNP25 and KCNMB4-CCND3 fusions significantly promoted cell migration of SAOS-2 cells. (B) Transwell invasion assay. While the LRP1-SNRNP25 promoted invasion of SAOS-2 cells significantly, KCNMB4-CCND3 fusions did not significantly promote cell invasion. (C) Wound healing assay showed that both fusions accelerated the osteosarcoma cell migration.