Table 1.

Accumulation of TAU in Central Brain Neurons Does Not Affect Viability

	% Survival
Genotype	Day 1	Day 7	Day 14	Day 21	Day 30
c492/+	100 ± 0	84.7 ± 1.5	77.9 ± 3.1	68.9 ± 4.2	64.4 ± 3.2
c772/+	100 ± 0	88.7 ± 3.9	76.2 ± 2.9	71.7 ± 3.6	66.1 ± 3.6
UAS-btau/+	100 ± 0	86.9 ± 3.7	79.5 ± 4.1	68.8 ± 2.9	62.8 ± 4.3
UAS-htauwt1/+	100 ± 0	83.5 ± 3.6	78.6 ± 5.6	69.5 ± 3.6	66.7 ± 3.8
UAS-dtau1/+	100 ± 0	86.5 ± 3.2	81.9 ± 4.3	74.9 ± 6.1	63.7 ± 4.8
UAS-dtau1/+ at 29°C	100 ± 0	80.7 ± 2.9	71.3 ± 3.8	66.7 ± 4.6	61.9 ± 5.3
UAS-dtau 4/+	100 ± 0	83.4 ± 3.5	78.8 ± 2.7	70.3 ± 3.1	63.4 ± 3.7
c492/+; UAS-btau/+	100 ± 0	87.8 ± 4.3	78.1 ± 3.1	71.2 ± 4.9	65.4 ± 4.2
c492/+; UAS-htauwt1/+	100 ± 0	84.6 ± 3.2	78.6 ± 4.3	72.5 ± 3.8	64.5 ± 3.9
c492/+; UAS-dtau1/+	100 ± 0	84.8 ± 3.4	77.6 ± 4.9	72.3 ± 4.3	66.2 ± 3.7
c492/+; UAS-dtau1/+ at 29°C	100 ± 0	83.7 ± 4.2	73.7 ± 3.7	67.2 ± 3.9	59.5 ± 4.7
c492/+; UAS-dtau4/+	100 ± 0	86.2 ± 4.2	78.1 ± 3.1	73.6 ± 3.5	66.3 ± 2.4
c772/+; UAS-btau/+	100 ± 0	87.1 ± 3.5	77.4 ± 3.3	69.7 ± 3.9	63.2 ± 3.3
c772/+; UAS-htauwt1/+	100 ± 0	83.9 ± 4.6	78.8 ± 3.7	72.7 ± 4.7	67.6 ± 5.1
c772/+; UAS-dtau1/+	100 ± 0	89.7 ± 3.9	83.6 ± 3.8	73.7 ± 2.8	64.8 ± 3.9
c772/+; UAS-dtau1/+ at 29°C	100 ± 0	80.3 ± 3.6	72.8 ± 4.2	62.7 ± 4.6	58.6 ± 5.4
c772/+; UAS-dtau4/+	100 ± 0	87.6 ± 3.2	80.2 ± 2.9	76.9 ± 2.4	67.1 ± 4.4

Survival of mixed-sex populations of the indicated genotypes was monitored over 4 wk and expressed as the percentage of starting animals alive on the indicated days. There was no significant difference in survival of all strains on day 7 (F_{(1, 76)} = 0.856, NS), day 14 (F_{(1, 71)} = 0.386, NS), day 21 (F_{(1, 74)} = 1.453, NS), and day 30 (F_{(1, 70)} = 0.659, NS). Although not significantly different from controls, survival of UAS-dtau1/+ and experimental animals (c492/+; dtau1/+; and c772/+; dtau1/+) exposed to 29°C appeared somewhat reduced.