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. 2014 Oct 1;15(1):834. doi: 10.1186/1471-2164-15-834

Table 1.

GO terms and KEGG pathways enriched with candidate genes for high-altitude adaptation in Tibetan pigs a

Population ID Term P-value Associated gene
GO
Gansu GO:0030011 Maintenance of cell polarity 0.001 ANK1, ANKH, DST
GO:0007270 Neuron-neuron synaptic transmission 0.018 GRIA1, GRIA4, GRM4, GRM5, HTR2A, VDAC1
GO:0030282 Bone mineralization 0.028 ANKH, BMP2, CLEC3B, LTF, TCF7L2
GO:0032663 Regulation of interleukin-2 production 0.041 MALT1, PDE4D
GO:0048566 Embryonic digestive tract development 0.041 GLI3, TCF7L2
GO:0060840 Artery development 0.041 CHD7, FOXS1, GLI3, MYLK2
GO:0018345 Protein palmitoylation 0.042 HHAT, ZDHHC3, ZDHHC7
GO:0016339 Calcium-dependent cell-cell adhesion 0.048 CDH13, CDH17, CDH19
Tibet GO:0050974 Detection of mechanical stimulus involved in sensory perception 0.029 GRIN2B, ITGA2, PCDH15
GO:0048661 Positive regulation of smooth muscle cell proliferation 0.041 ID2, ITGA2
GO:0060079 Regulation of excitatory postsynaptic membrane potential 0.041 GRIN2B, SEZ6
GO:0010922 Positive regulation of phosphatase activity 0.042 ITGA2, MAGI2, PLEK
GO:0031532 Actin cytoskeleton reorganization 0.049 ABL1, CSF1R, PARVA, PLEK
Sichuan & Yunnan GO:0097091 Synaptic vesicle clustering 0.010 NRXN1, SYNDIG1
GO:0072337 Modified amino acid transport 0.024 FOLR1, FOLR2, SLC1A4
GO:0072520 Seminiferous tubule development 0.034 ING2, SPINK2
GO:0021575 Hindbrain morphogenesis 0.039 FAIM2, NRXN1
GO:0060079 Regulation of excitatory postsynaptic membrane potential 0.039 GRIK2, NRXN1
GO:1902930 Regulation of alcohol biosynthetic process 0.039 APOB, TWIST1
GO:0017158 Regulation of calcium ion-dependent exocytosis 0.042 B4GALT1, PLCB1, SYT1
GO:0006208 Pyrimidine nucleobase catabolic process 0.042 DPYS, DPYSL3
GO:0007215 Glutamate receptor signaling pathway 0.042 GRIK2, HOMER2, NRXN1, PLCB1
Overall GO:0010712 Regulation of collagen metabolic process 0.002 CST3, ITGA2, PDGFRB, RGCC
GO:0051567 Histone H3-K9 methylation 0.018 DNMT3B, KDM1A, PRDM5
GO:0050927 Positive regulation of positive chemotaxis 0.033 CDH13, CNTN1, ITGA2
GO:0032465 Regulation of cytokinesis 0.038 PDZD2, TEX14
GO:0019626 Short-chain fatty acid catabolic process 0.043 MUT, PCCA
GO:0050966 Detection of mechanical stimulus involved in sensory perception of pain 0.043 GRIN2B, ITGA2
GO:0002209 Behavioral defense response 0.045 GRIN2B, NR2E1, VDAC1
KEGG
Gansu KEGG:05217 Basal cell carcinoma 0.031 BMP2, GLI3, TCF7L2
KEGG:04713 Circadian entrainment 0.033 ADCY10, GRIA1, GRIA4, RPS6KA5
KEGG:05033 Nicotine addiction 0.043 GRIA1, GRIA4
KEGG:04520 Adherens junction 0.045 NLK, PTPRB, TCF7L2
Tibet KEGG:00640 Propanoate metabolism 0.004 ACACB, PCCA, SUCLG2
KEGG:00920 Sulfur metabolism 0.004 IMPAD1, PAPSS2
KEGG:03030 DNA replication 0.024 PRIM2, RPA1
Overall KEGG:00280 Valine, leucine and isoleucine degradation 0.036 ACADSB, MUT, PCCA
KEGG:04975 Fat digestion and absorption 0.042 APOB, PLA2G12A
KEGG:05014 Amyotrophic lateral sclerosis (ALS) 0.046 DAXX, GRIN2B, MAP2K6

a P-values after Bonferroni correction for multiple testing. Overall indicates all Tibetan pig populations.