Figure 3.

The development of spatial memory for a platform location during the probe trials administered 1 h (A) and 24 h (B) after training in a cued reference memory version of the Morris water maze test. An annulus crossing index represents the average frequency of swims over the platform site in a target quadrant adjusted for swims over sites in other quadrants of the pool. Both TgCRND8 and non-Tg littermates showed a comparable spatial memory for the platform site (left panels), and a comparable search preference of the (NE) target quadrant (top right panels of A and B) in both probe trials. Search preference was calculated by dividing the surface area of the pool into 144 (12 × 12) tiles (Wintrack program), and calculating for each tile the ratio of the time spent by a mouse in this tile to the time expected by chance. Values >1 (lighter color) indicate a preference for the respective area of the pool. Representative search paths for mice of each genotype are provided below each surface preference panel. Vertical bars represent SEM.