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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Am J Phys Med Rehabil. 2014 Nov;93(11 0 3):S169–S175. doi: 10.1097/PHM.0000000000000147

Figure 1. Differences in harvest, processing and delivery of First Generation, Purified and Next Generation progenitors.

Figure 1

First Generation stem cells are harvested from source tissue and delivered without significant processing as mixed progenitor pools. In contrast, Purified biologics utilize a cell purification step to isolate specific cell phenotypes from source tissue, eliminating cells devoid of regenerative benefit. Next Generation stem cell therapy introduces the concept of lineage specification by either harvesting regenerative stem cells from the heart, or by guiding them with a process termed cardiopoiesis to yield a pure population of progenitors guided for maximal regenerative potency.