Table 2. Univariate and multivariate analysis of prognostic factors in HCC for disease-free survival.
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
HR | p > |z| | 95% CI | HR | p > |z| | 95% CI | |
MAGE-A9 expression | ||||||
High versus Low | 3.39 | 0.001* | 1.898–6.046 | 2.54 | 0.006* | 1.299–4.954 |
Gender | ||||||
Male versus Female | 1.08 | 0.648 | 0.580–2.403 | |||
Age (years) | ||||||
<60 versus ≥60 | 1.66 | 0.146 | 0.838–3.285 | |||
Tumour size (cm) | ||||||
>5 versus ≤5 | 1.83 | 0.031* | 1.057–3.177 | 1.44 | 0.255 | 0.768–2.707 |
α-fetoprotein status | ||||||
High versus Low | 1.01 | 0.971 | 0.603–1.692 | |||
Hepatitis B virus infection | ||||||
Positive versus Negative | 1.21 | 0.486 | 0.699–2.128 | |||
Liver cirrhosis | ||||||
Positive versus Negative | 0.89 | 0.660 | 0.522–1.509 | |||
Pathological grade | ||||||
Grade 1 and 2 versus Grade 3 | 0.45 | 0.007* | 0.252–0.807 | 0.74 | 0.378 | 0.384–1.438 |
Portal vein invasion | ||||||
Positive versus Negative | 3.26 | 0.001* | 1.930–5.520 | 1.79 | 0.073 | 0.948–3.368 |
Lymph node metastasis | ||||||
Positive versus Negative | 2.67 | 0.001* | 1.548–4.605 | 2.29 | 0.008* | 1.238–4.229 |
Distant metastasis | ||||||
Positive versus Negative | 2.52 | 0.035* | 1.068–5.966 | 0.60 | 0.317 | 0.216–1.644 |
TNM stage | ||||||
Stage I-II versus Stage III-IV | 0.32 | 0.001* | 0.184–0.565 | 0.77 | 0.480 | 0.370–1.598 |
MAGE-A9 expression+ α-fetoprotein status | ||||||
Both high versus Others situations (High + Low or Low + High or Both low) | 1.60 | 0.093 | 0.925–2.785 |
*p < 0.05.