Table 1. Characteristics of studies included in this meta-analysis.
| Surname | Year | Country | Ethnicity | Cancer type | Control source | Genotyping methods | Cases/Control | D. Case | D. Control | HWE |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1805388 | ||||||||||
| Roddam | 2002 | UK | Caucasian | acute lymphoblastic leukemia | NA | PCR | 70/220 | 0/21/49 | 13/58/149 | 0.03 |
| Roddam | 2002 | UK | Caucasian | lymphoma | NA | PCR | 362/220 | 7/108/247 | 13/58/149 | 0.03 |
| Roddam | 2002 | UK | Caucasian | multiple myeloma | NA | PCR | 269/220 | 4/61/204 | 13/58/149 | 0.03 |
| Fu | 2003 | China | Asian | breast cancer | socioeconomic status | MassARRAY | 253/376 | 16/100/137 | 28/150/198 | 0.955 |
| Garcia-Closas | 2006 | USA | Caucasian | breast cancer | Age | Taqman | 1316/1043 | 57/339/920 | 42/277/724 | 0.199 |
| Hill | 2006 | USA | Caucasian | non-Hodgkin lymphoma | Age, gender | Taqman | 1110/931 | 18/300/792 | 28/275/628 | 0.75 |
| Wu | 2006 | China | Asian | bladder cancer | Age, gender | PCR-RFLP | 606/593 | 24/168/414 | 15/194/384 | 0.099 |
| Andreae | 2007 | Germany | Caucasian | acute lymphoblastic leukemia | Age, gender | DHPLC | 107/104 | 3/19/85 | 3/33/68 | 0.673 |
| Werbrouck | 2008 | Belgium | Caucasian | head and neck cancer | Age, gender | PCR-RFLP | 152/157 | 3/30/119 | 8/44/105 | 0.242 |
| Tseng | 2009 | Taiwan | Asian | lung cancer | Age, gender | PCR | 149/152 | 20/62/67 | 12/55/85 | 0.464 |
| Li | 2009 | USA | Caucasian | pancreatic cancer | Age, gender | Taqman | 723/776 | 23/197/503 | 29/208/539 | 0.117 |
| Gomes | 2010 | Portugal | Caucasian | thyroid cancer | Age, gender | Real-Time PCR | 109/217 | 4/22/83 | 5/54/158 | 0.879 |
| Al-Hadyan | 2012 | Saudi Arabia | Asian | head and neck cancer | Age | PCR | 156/251 | 0/24/132 | 4/31/216 | 0.029 |
| Salagovic | 2012 | Slovakia | Caucasian | lymphoma | NA | PCR | 107/127 | 1/26/80 | 2/32/93 | 0.688 |
| Zhao | 2013 | China | Asian | glioma | Age, gender | PCR | 384/384 | 49/172/163 | 20/142/222 | 0.659 |
| rs1805386 | ||||||||||
| Kuschel | 2002 | Germany | Caucasian | breast cancer | NA | PCR | 1440/2016 | 20/322/914 | 50/492/1248 | 0.857 |
| Han | 2004 | USA | Caucasian | breast cancer | Age, BMI | Taqman | 977/1266 | 22/274/681 | 32/360/874 | 0.48 |
| Garcia-Closas | 2006 | USA | Caucasian | breast cancer | Age | Taqman | 1338/1057 | 55/379/904 | 34/309/714 | 0.934 |
| Jakubowska | 2010 | Germany | Caucasian | breast cancer | NA | PCR | 319/290 | 112*/207 | 94*/196 | NA |
| Jakubowska | 2010 | Germany | Caucasian | ovarian cancer | NA | PCR | 145/280 | 54*/91 | 92*/188 | NA |
| Assis | 2010 | Portugal | Caucasian | ovarian cancer | NA | Real-Time PCR | 126/198 | 7/36/83 | 5/60/133 | 0.562 |
NA: not available; D.: distribution;
*: homozygous variants + heterozygous variant (CC + TC); HWE: Hardy-Weinberg Equilibrium.