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. 2014 Sep 12;3(10):924–936. doi: 10.1242/bio.20148185

Fig. 5. p85β is essential for maintenance of cell adhesions depth in melanoma cells.

Fig. 5.

BLM cells were transfected with control or p85β siRNA (48 h), then stained with anti-paxillin Ab. Representative images at indicated z-sections; bar  =  12 µm. Arrows indicate adhesions that extended >2 µm in the z-axis (1 µm step size). Cell extracts were analyzed in WB. Graphs show the number of adhesions (>2 µm depth), and the mean depth of cell adhesions in control and p85β-depleted cells (mean ± s.d.; n  =  25). (***) P <0.001; Student's t test.