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. 2014 Sep 26;3(10):995–1004. doi: 10.1242/bio.20148227

Fig. 3. Intracellular domains of syndecan-4 are involved in RANTES/CCL5-mediated HUV-EC-C spreading and vascular tube formation.

Fig. 3.

HUV-EC-C transfected with GFP plasmid (control), SDC4WT-GFP (SDC4WT) or mutated SDC-4 constructs (S179A, L188QQ, A198del) were stimulated or not by 3 nM RANTES/CCL5 and assayed for cell spreading on fibronectin (A) or vascular tube formation in Matrigel (B). Results are expressed as area (A) or as length of vascular sprout (B) (mean ± SEM) expressed in arbitrary units (A.U.). The vertical axis ranges from (A) 0.1 to 0.15 or from (B) 0.5 to 0.85 A.U. * P<0.05, RANTES/CCL5 versus control; # P<0.05, S179A versus SDC4 (in the absence of RANTES/CCL5); $ P<0.05 SDC4WT versus control (in the presence of RANTES/CCL5).