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. 2014 Aug;141(16):3153–3158. doi: 10.1242/dev.111427

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Normal NC migration in Vangl1/2 double mutants and after acute Vangl2 downregulation in the NC lineage. (A-H) Control (A,C-E; Vangl1^gt/+; Vangl2^Δ/+) and double-mutant (B,F-H; Vangl1^gt/gt; Vangl2^Δ/Δ) embryos exhibit normal migration of Erbb3-positive cranial NC (E8.5; A,B) and cranial/trunk NC (E9.5; C-H). Acute NC downregulation of Vangl2 to test for a possible compensatory mechanism in Vangl2^Lp/Lp embryos (I) reveals identical YFP-positive NC migration in control (J-L; Vangl2^+/flox; Wnt1-Cre) and downregulation (M-O; Vangl2^Lp/flox; Wnt1-Cre) E9.5 embryos. Arrows indicate comparable streams of NC cells migrating from the trunk neural tube in both genotypes. Scale bars: 200 µm in A; 500 µm in C,F; 100 µm in J-O.