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. 2014 Nov;96(5):895–905. doi: 10.1189/jlb.3A0114-056RR

Figure 1. The absence of TLR4 increases CD4 cell inflammatory cytokine production.

Figure 1.

(A) Total spleen CD4 cells from TLR4−/−, IL-10−/−, TLR4−/−IL-10−/− [double-knockout (dKO)], and WT mice were analyzed for IFN-γ and IL-17 production. (B) IFN-γ and IL-17 expression from total CD4+ T cells in the spleen and intestine. Bar charts reflect mean ± sem. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with WT mice. Data are representative of three or more experiments of two or more mice/group with similar results. FACS plots are gated upon live CD4+ cells.