Skip to main content
. 2014 Aug 5;3(3):824–847. doi: 10.3390/cells3030824

Figure 4.

Figure 4

The 19S cap of the proteasome has functional and structural similarities with Cdc48p/p97. Like Cdc48p/p97, the hexameric 19S cap of the proteasome binds simultaneously to E3 ligases and to DUBs, suggesting that PUCs are processed at this stage, immediately before substrate degradation. This could be needed for the transfer of the substrate from the periphery of the proteasomal lid through its central pore and further into the proteolytic chamber of the proteasome. Immediately before passage through the pore of the l9S cap, structural data suggest that all PUCs are to be removed. See text for details.