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. 2014 Jul 22;3(3):724–750. doi: 10.3390/cells3030724

Figure 2.

The miR-1 family.

Figure 2

miR-1 and miR-133a are two closely related, striated muscle-enriched miRNAs that are transcribed together as members of a bicistronic cluster. The vertebrate genome contains two copies of the miR-1/133a locus on different chromosomes. The miR-1-1/133a-2 cluster is located within an intergenic region of chromosome 2, while the miR-1-2/133a-1 cluster is encoded within an intron of the protein-coding Mindbomb (Mib) gene. An additional intergenic miRNA cluster consisting of miR-206 and miR-133b is located on chromosome 1. This cluster is homologous to miR-1, but is expressed exclusively in skeletal muscle.