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. 2014 Oct 15;6:285. doi: 10.3389/fnagi.2014.00285

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Copyright © 2014 Mancuso, Baglio, Agostini, Cabinio, Laganà, Hernis, Margaritella, Guerini, Zanzottera, Nemni and Clerici.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Region of interest (ROI) Analysis. (A) ROIs location and relative MNI coordinates (x,y,z). (B) Scatterplots representing the correlation between ROIs volumes of both MCI (blue circles) and AD (orange squares) subjects vs. herpes simplex virus 1 (HSV-1)-specific Ab titers. (C) Bar charts and error bars representing ROI volumes (mean with SEM) in the three groups. Post hoc results are illustrated (*p < 0.05; **p < 0.01; ***p < 0.001). ROFC, right orbitofrontal cortex; LTP, left temporal lobe; RTL, right temporal lobe; RDLPFC, right dorsolateral prefrontal cortex; AD, Alzheimer’s disease; aMCI, amnestic mild cognitive impairment; R_Sp, Spearman correlation coefficient.