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. 2014 Aug;141(15):2984–2992. doi: 10.1242/dev.109827

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Slmb is required for the localisation of oskar mRNA. (A-C) GFP-Stau localisation in wild-type (A) and slmb^9H4-17 Drosophila germline clones (B,C). GFP-Stau localises to the middle of most slmb mutant oocytes (B), but sometimes appears to be falling off from the posterior cortex (C). (D) The quantification of Stau localisation in stage 9-11 oocytes in: (1) w^– (WT); (2) slmb^9H4-17 germline clone (9H4); (3) slmb^8A6-5 germline clone (8A6); (4) hs-Slmb; slmb⁸/slmb^9H4-17 (9H4/8); and (5) nanos-Gal4VP16; UASGFP-Slmb; hs-Slmb, slmb⁸/slmb^9H4-17 (GFPSlmb;9H4/8). (E-G) In situ hybridisations for oskar (osk) mRNA. osk mRNA (red) localises to the posterior of wild-type oocytes (E), but is found in the middle (F) or extending from the posterior (G) of slmb^9H4-17 germline clone oocytes. (H) Example of the variable Stau localisation phenotype of hs-Slmb, slmb⁸/slmb^9H4-17. (I) Molecular characterisation of slmb alleles. slmb^9H4-17 contains a nonsense mutation at amino acid 167. slmb^8A6-5 has an alanine-to-valine substitution at amino acid 429. The F-box domain and the WD40 repeats of Slmb are shown.