Fig. 6.

Loss of PGCs and defects in skeletal patterning in Bmp4^S2KHAmyc/S2G compound mutants. (A) Schematic illustration of heterodimeric BMP4 precursor protein and cleavage products predicted to form in Bmp4^S2KHAmyc/S2G compound mutants. (B) PGC number versus somite pairs at E9 demonstrates a more severe reduction in PGC number in Bmp4^S2KHAmyc/S2G compound mutants than in either single mutant. (C) Dorsal view of representative skeletal preparations showing normal (left panel), or examples of mild (center panel) or severe (right panel) defects in vertebral fusion (white arrows).